Why Was The Whi Study Terminated Early?

One treatment-arm of the Women's Health Initiative (WHI) study was recently terminated because the overall risks of hormone treatment were considered to outweigh the benefits. The main findings were an increased risk of venous thromboembolism and a decreased risk of osteoporotic fractures with treatment.May 15, 2003

[After the early termination of the Women's Health Initiative ...

How has the use of menopausal hormone therapy changed since the women's Health Initiative study?

Instead, the Women's Health Initiative study found that taking estrogen plus progestin hormone replacement therapy — HRT — actually increased a woman's risk of heart disease and breast cancer. The study had a huge effect: Within months the number of women using HRT dropped by almost half.

The Last Word On Hormone Therapy From the Women's Health Initiative ...

What did the women's Health Initiative accomplish?

The WHI demonstrated that the use of estrogen plus progestin hormone therapy after menopause increased the risk for heart disease, stroke, blood clots, breast cancer, and dementia.

Women's Health Initiative (WHI) | NHLBI, NIH

When was the women's Health Initiative study?

In 1991, the National Heart, Lung, and Blood Institute, part of NIH, launched the Women's Health Initiative (WHI) to understand better how these diseases affect post-menopausal women and to reduce the number of women who develop and die from these diseases.

Largest women's health prevention study ever – Women's Health Initiative

Why was the women's Health Initiative WHI study researching the effects of menopausal hormone therapy MHT discontinued?

After the July 2002 Women's Health Initiative (WHI) trial announcement that estrogen-progestin therapy was being halted prematurely due to safety concerns, prevalence of prescription menopausal hormone therapy (MHT) declined dramatically.

Menopausal Hormone Therapy Trends Before Versus After 2002

Related Links

Group Reacts to Early Termination of the WHI Estrogen-Alone ...
... to the National Institute of Health's decision to terminate early the estrogen-alone portion of the Women's Health Initiative study. - www.newswise.com

HRT arm of WHI stopped - Medscape
The trial was suspended on May 31, 2002, after 5.2 of a projected 8.5 years of follow-up, because of the safety concerns. Full results are ... - www.medscape.com

HRT: The history - Women's Health Concern
2002 WHI study stopped the combined (estrogen and progestogen) HRT arm of the study prematurely in light of findings of safety issues with ... - www.womens-health-concern.org

Ripples From Original WHI Study Results Continue - Relias ...
The initial report that the WHI was being terminated early because of safety concerns changed our views on MHT forever. - www.reliasmedia.com

Risks and Benefits of Estrogen Plus Progestin in Healthy ...
The WHI is the first randomized trial to directly address whether estrogen plus progestin has a favorable or unfavorable effect on CHD incidence ... - jamanetwork.com

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